Untitled Document
Untitled Document
Current issue
Past issues
Topic collections
e-journal Editor page

Hypersensitivity Reactions Induced by Paclitaxel : Focus on Premedication

การให้ยาป้องกันการเกิดภาวะภูมิไวเกิน(Hypersensitivity reactions )จากยา Paclitaxel

Chumnan Kietpeerakool (ชำนาญ เกียรติพีรกุล) 1

การให้ยาป้องกันการเกิดภาวะภูมิไวเกิน(Hypersensitivity reactions )จากยา Paclitaxel

นายแพทย์ ชำนาญ เกียรติพีรกุล

สาขาวิชามะเร็งวิทยานรีเวช ภาควิชาสูติศาสตร์และนรีเวชวิทยา คณะแพทยศาสตร์ มหาวิทยาลัยเชียงใหม่  จังหวัดเชียงใหม่ 50200 

Hypersensitivity Reactions Induced by Paclitaxel  : Focus on Premedication

Chumnan Kietpeerakool

Department of Obstetrics and Gynecology Faculty of Medicine, Chiang Mai University

Chiang Mai 50200, Thailand       

Purpose of review

            Paclitaxel is widely employed in standard oncologic treatment including cancer of ovary, breast and lung. Although it is generally well tolerate, some potential serious adverse affects had been reported especially hypersensitivity reaction which became the most characteristics toxicity and could be prevented by various prophylactic treatments. This review summarized the results from published studies which conducted to investigate the efficacy of prophylactic management, of particular interest in premedication regimen.

Relevant findings

            The overall incidence of hypersensitivity reaction of paclitaxel had been reported in up to 40% in phase I study. The polyoxyethylated castor oil or cremophor EL which dissolved  paclitaxel was thought to be causative based on animal study and experience in  other drugs formulated in this solvent. After the introduction of the standard premedication regimen consisted of 20 mg dexamethasone orally or intravenously 12 and 6 hours before treatment, 50 mg diphenhydramine (H1 antagonist), 20 mg famotidine (H2 antagonist)  intravenously 30 minutes before infusion of paclitaxel, the incidence of major hypersensitivity reaction had decreased to be approximately 1- 2%. However, this regimen is quite inconvenient. So the modified regimen consisted of 20 mg dexamethasone intravenously at the same time as histamine-antagonist drugs administration was proposed and demonstrated its effectiveness as the standard regimen. Although current data from several retrospective analyses comparing the effectiveness of both prophylactic regimens are still inconclusive, it is clear that both premedication regimens have not completely eliminate major drug reaction. Thus, the patient who treated with paclitaxel should be actively monitored and recognized for this adverse affect regardless of premedication type. . . . Full text.

Untitled Document
Article Location

Untitled Document
Article Option
       PDF File
Untitled Document
ทำหน้าที่ ดึง Collection ที่เกี่ยวข้อง แสดง บทความ ตามที่ีมีใน collection ที่มีใน list Untitled Document
Another articles
in this topic collection

Heman Genome Project and Infertility Practice (โครงการจีโนมมนุษย์กับการดูแลรักษาภาวะมีบุตรยาก)
Prevalence of Anemia in Pregnant Women at Srinagarind Hospital (ความชุกของภาวะเลือดจางในสตรีตั้งครรภ์ที่มาฝากครรภ์ที่โรงพยาบาลศรีนครินทร์)
Molar Pregnancy in Srinagarind Hospital (ภาวะครรภ์ไข่ปลาอุกในโรงพยาบาลศรีนครินทร์)
Emergency Contraception (การคุมกำเนิดฉุกเฉิน)
Untitled Document
This article is under
this collection.

Obstetric and Gynecology
Srinagarind Medical Journal,Faculty of Medicine, Khon Kaen University. Copy Right © All Rights Reserved.


Warning: Unknown: Your script possibly relies on a session side-effect which existed until PHP 4.2.3. Please be advised that the session extension does not consider global variables as a source of data, unless register_globals is enabled. You can disable this functionality and this warning by setting session.bug_compat_42 or session.bug_compat_warn to off, respectively in Unknown on line 0