Metastasis is a process that cancer cells spread from a primary site to different parts of the body. It is the major cause of cancer death. The metastasis involved multiple sequential steps in which numerous biochemical molecules have been implicated in the process. Insight understanding the role of such molecular components is important for metastasis prevention and inhibition. To produce clinically effective therapeutic outcomes, several compounds targeting metastasis processes have been developed and are currently under study in various phases of clinical testing for treatment of metastatic cancers, in expectation, further reduce cancer mortality rate.