Objective: To investigate the association between antibiotic-treated patients in Roi Et hospital and their risk of infection with extended spectrum beta-lactamase producing Escherichia coli ESBL-E.coli.
Methods: A hospital based case-controls study and data were collected from medical records of patients at Roi Et hospital between January 1, 2015 to December 31, 2017. Descriptive statistics, univariable analysis and multivariable analysis by multiple logistic regressions were used for data analysis. The statistically significant was set at p <0.05.
Results: Of 125 cases most of them were female 51.0% with mean age 63.2 +10.6 years. Whereas 250 controls most of them were male 55.0% with mean age 56.0 +11.4 years. The multiple logistic regressions analyzed revealed that patients treatment with carbapenems (OR Adj. =2.1; 95%CI: 1.98-4.41) and third generation cephalosporin (OR Adj. =3.2; 95%CI: 1.95-6.93) were risk factors of infection with ESBL-E.coli.
Conclusion: This study revealed the association of patients treated with either carbapenems and third generation cepahrosporin and their risks to be infected with ESBL-E.coli.